Reduced Incidence of Long-COVID Symptoms Related to Administration of COVID-19 Vaccines Both Before COVID-19 Diagnosis and Up to 12 Weeks After
December 15, 2021
Clinical trials and studies of real-world evidence have demonstrated repeatedly that the three COVID-19 vaccines* authorized for emergency use or approved for use by the Food and Drug Administration are safe and effective at preventing COVID-19 infection, hospitalization, and death (1). A recent observational study of self-reported symptoms goes further, concluding that vaccination may also reduce the likelihood and intensity of long-COVID (2), a proposal that has been raised anecdotally, as well (3). As part of a federated research study with the COVID-19 Patient Recovery Alliance, Arcadia.io performed a retrospective analysis of the medical history of 240,648 COVID-19-infected persons to identity factors influencing the development and progression of long-COVID. This analysis revealed that patients who received at least one dose of any of the three COVID vaccines prior to their diagnosis with COVID-19 were 7-10 times less likely to report two or more long-COVID symptoms† compared to unvaccinated patients. Furthermore, unvaccinated patients who received their first COVID-19 vaccination within four weeks of SARS-CoV-2 infection were 4-6 times less likely to report multiple long-COVID symptoms, and those who received their first dose 4-8 weeks after diagnosis were still 3 times less likely to report multiple long-COVID symptoms compared to those who remained unvaccinated. This relationship supports the hypothesis that COVID-19 vaccination is protective against long-COVID and that that effect persists even if vaccination occurs up to 12 weeks after COVID-19 diagnosis.
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